On the design of precision nanomedicines
WebIn recent years, tremendous efforts have been devoted to developing smart transformable anticancer nanomedicines. Herein, we provide a review to outline the advances in this emerging field. First, smart size-reducible nanoparticles (NPs) for deep tumor penetration are summarized, including carrier degradation-induced, protonation-triggered and ... Web1 de mar. de 2024 · Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment Author links open overlay panel Xiao Zhao a b 2 , Xiuchao Wang b 2 , Wei Sun b 2 1 , Keman Cheng a , Hao Qin a , Xuexiang Han a , Yu Lin d , Yongwei Wang a , Jiayan Lang a , Ruifang Zhao …
On the design of precision nanomedicines
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Web12 de set. de 2024 · Gas therapy is an emerging and promising field, utilizing the unique therapeutic effects of several kinds of gases (NO, CO, H 2 S and H 2) towards many major diseases, including cancer and cardiovascular diseases, and it is also facing challenges relating to enhancing gas therapy efficacy and avoiding gas poisoning risks.Here, we … Web22 de mai. de 2024 · This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.
WebConventional mitochondrial targeting strategies can hardly distinguish the mitochondria in cancer cells from those in normal cells, which might raise a concern about the biosafety. Recent studies suggest that a relatively high temperature of mitochondria exists in cancer cells. We named it tumor intrinsic mitochondrial overheating (TIMO). WebOn the design of precision nanomedicines Xiaohe Tian1,2,3, Stefano Angioletti-Uberti4,5, Giuseppe Battaglia2,6,7,8* Tightcontrolontheselectivityofnanoparticles ’interactionwithbiologicalsystemsisparamountforthedevelopment of targeted therapies. However, the large number of tunabl e parameters makes it difficult to identify …
WebNanomedicines can be functionalized using targeted ligand and stimuli-responsive systems to reinforce their efficacy and minimize off-target effects. This review expounds on various biomimetic systems and their functionalization for the therapeutic targets of arthritis treatment, and discusses the challenges for the clinical translation of the biomimetic system. WebTitle: On the design of precision nanomedicines: Authors: Tian, X Angioletti-Uberti, S Battaglia, G: Item Type: Journal Article: Abstract:
Web7 de fev. de 2024 · In the following subsections, we discuss the various nanomedicines and precision medicines developed by using 3D printing. Basically, many nanomedicines are currently under development to be used as precision medicine, and 3D printing is also being investigated for the design of these nanomedicines.
Web1 de mar. de 2024 · To precisely design nanotherapeutics specifically for GEM chemosensitivity in pancreatic cancer treatment, a nanocarrier with features specifically targeting hENT1 low or RRM2 high was created as shown in Fig. 2 A. Dioleoyl-trimethylammonium propane (DOTAP)-based cationic liposomal nanoparticles (NP) were … earring with chainWeb1 de out. de 2024 · Herein, the advances in AI-enabled nanomedicines in cancer management are elaborated and their application in diagnosis, monitoring and therapy as well in precision medicine development is discussed. RGD peptide modified platinum nanozyme Co-loaded glutathione-responsive prodrug nanoparticles for enhanced chemo … ctb housekeeping suppliesWeb1 de ago. de 2016 · Request PDF Abstract B39: Identifying molecular signatures of tumor dormancy as a basis for the rational design of precision nanomedicines Tumor progression is dependent on a number of ... ctbhp beaconhealthoptions.comWeb12 de abr. de 2024 · Alannah Hallas and co-workers have written a comprehensive overview of current research, focusing on the different facets of a class of high entropy materials called high-entropy oxides (HEOs) (DOI: 10.1021/jacs.2c11608).The researchers establish what defines HEOs, as well as their nomenclature, and discuss the stabilization and … ctbhp formsWeb13 de nov. de 2015 · Research field: Design, synthesis and structural optimization of functionalized small molecules as anticancer agents (CK2, ERK), efflux pump inhibitors (P-gp, BCRP) and anti-infective agents (CYP51, MBLs). Some heterocyclic scaffolds developed: indole, indeno[1,2-b]indole. Kinetics of organosilicates and clay complexation … ctbh norwichWebAI-enabled nanotechnology could improve the accuracy of molecular profiling and early diagnosis of patients, and optimize the design pipeline of nanomedicines by tuning the properties of nanomedicines, achieving effective drug synergy, and decreasing the nanotoxicity, thereby, enhancing the targetability, personalized dosing and treatment … ctbhp log in pageWeb24 de jan. de 2024 · Tight control on the selectivity of nanoparticles' interaction with biological systems is paramount for the development of targeted therapies. However, the large number of tunable earring with cross