WebDL-Buthionine-(S,R)-sulfoximine has also been used: to induce oxidative stress in Starlings; to deplete choroidal glutathione (GSH) in two-day-old rat pups; to test its inhibitory effect … WebFeb 13, 2008 · The structure of Leishmania major trypanothione synthetase-amidase, determined in three crystal forms, reveals two catalytic domains. The N-terminal domain, …
Dissecting the essentiality of the bifunctional trypanothione ...
WebThus, while a 48 h exposure to DFMO EC 50 was required to achieve a remarkable decrease in trypanothione levels, 105 RNAi silencing of trypanothione synthetase resulted in 90% depletion of trypanothione within 24 h. 70 Additional evidence obtained from T. cruzi for a protective role of trypanothione in Nfx mode of action is discussed later. WebDOI: 10.1016/S0166-6851(03)00176-2 Corpus ID: 11475314; Properties of trypanothione synthetase from Trypanosoma brucei. @article{Oza2003PropertiesOT, title={Properties of trypanothione synthetase from Trypanosoma brucei.}, author={Sandra L. Oza and Mark R. Ariyanayagam and Niall Aitcheson and Alan H. Fairlamb}, journal={Molecular and … northland metal roofing
Leishmania Trypanothione Synthetase-Amidase Structure Reveals …
WebK01833 TRYS; trypanothione synthetase/amidase 6. Ligases 6.3 Forming carbon-nitrogen bonds 6.3.1 Acid-D-ammonia (or amine) ligases (amide synthases) 6.3.1.9 trypanothione … WebJul 15, 2024 · Trypanosomatid-caused diseases are among the neglected infectious diseases with the highest disease burden, affecting about 27 million people worldwide … WebApr 24, 1990 · Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities. Journal of Biological … northlandmgt.com